Enclomiphene Citrate

Overview of Enclomiphene

Enclomiphene is the trans stereoisomer of clomiphene citrate. It belongs to the class of non-steroidal selective estrogen receptor modulators (SERMs). It shows competitive antagonism at estrogen receptor binding sites. It is studied for its modulation of hypothalamic-pituitary feedback mechanisms in controlled research models. The compound is supplied as a crystalline research material. It is intended strictly for laboratory and mechanistic investigation.

Chemical and Molecular Properties

Property	Description
Chemical Name	Enclomiphene
Molecular Formula	C26H28ClNO
Molecular Weight	~405.96 g/mol
CAS Number	15690-57-0
Structural Class	Non-steroidal selective estrogen receptor modulator (SERM)
Appearance	White to off-white crystalline powder (typical)
Solubility	Research-grade solvent-specific (e.g., DMSO)
Research Classification	Estrogen receptor antagonist in experimental systems

Note: The trans configuration distinguishes enclomiphene from the zuclomiphene isomer that is present in clomiphene citrate mixtures.

Working Mechanism of Enclomiphene

Mechanistic Interaction with Estrogen Receptors

Enclomiphene functions as a selective estrogen receptor antagonist. It binds competitively to estrogen receptor subtypes. In research models, this antagonism brings estrogen-mediated negative feedback on the hypothalamus and anterior pituitary. This disrupts regulatory loops that control gonadotropin release.

Modulation of Hypothalamic-Pituitary Feedback

Once estrogen signaling is blocked, experimental studies report that the impaired negative feedback signal increases in gonadotropin-releasing hormone (GnRH) pulsatility. This upstream modulation has been shown in controlled environments to influence downstream luteinizing hormone (LH) and follicle‑stimulating hormone (FSH) output in endocrine research models.

Research Context of Signaling Pathways

In laboratory investigations, enclomiphene is a tool to explore endocrine axis dynamics, particularly how selective estrogen receptor modulation affects regulatory hormone networks, receptor occupancy, and secondary signaling cascades. Mechanistic insights are derived from tissue assays, receptor binding studies, and hormone feedback modeling rather than clinical efficacy outcomes.

Enclomiphene Research Applications (Laboratory Use Only)

Enclomiphene is utilized in controlled experimental research contexts, including:

• Investigational studies of selective estrogen receptor antagonism
• Analysis of hypothalamic-pituitary feedback mechanisms in endocrine models
• In vitro receptor binding and transactivation assays
• Preclinical pharmacodynamic research involving gonadotropin regulatory pathways

Applications are limited to mechanistic and analytical laboratory environments and do not imply validated outcomes in biological organisms outside controlled research.

Why Choose Purerawz for Enclomiphene?

Buy Enclomiphene for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note: Enclomiphene (C26H28ClNO) is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.

Reference Links

Wiehle, R. D., Fontenot, G. K., Wike, J., et al. (2014). Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial. Fertility and Sterility, 102(3), 720-727. https://doi.org/10.1016/j.fertnstert.2014.06.004/

Alexandre Hohl, M. P. Chavez, E. Pasqualotto, et al. (2025). Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials. Archives of Endocrinology and Metabolism, 69(5), e250093. https://doi.org/10.20945/2359‑4292‑2025‑0093/

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