Amino Tadalafil

Overview: Amino Tadalafil

Amino Tadalafil is an investigational compound. It is structurally related to tadalafil. Tadalafil is a molecule studied for its ability to inhibit phosphodiesterase type-5 (PDE5) in biochemical systems. PDE5 enzymes regulate intracellular signaling. They do that by controlling the breakdown of cyclic guanosine monophosphate (cGMP). For your information, cGMP is an important secondary messenger involved in nitric-oxide-dependent signaling pathways.

In experimental environments, compounds in the tadalafil class are often used to investigate:

• enzyme inhibition kinetics

• receptor signaling pathways

• and cyclic nucleotide metabolism

Amino-modified analogs are typically examined for differences in binding affinity, molecular stability, and enzyme selectivity. All these are relative to reference PDE5 inhibitors.

Amino Tadalafil

Property	Description
CAS Number	385769-84-6
Molecular Formula	C21H18N4O4
Molecular Weight	390.39 g/mol
Chemical Class	PDE5 inhibitor analog
Research Category	Enzyme-inhibition research compound
IUPAC Name	(2R,8R)-6-amino-2-(1,3-benzodioxol-5-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione

What Is Amino Tadalafil?

As we talked about earlier, Amino Tadalafil is a structural analog of tadalafil. It is designed for research on the inhibition of cGMP-specific phosphodiesterase type 5 (PDE5). The parent compound tadalafil was identified as a highly selective PDE5 inhibitor with strong binding affinity for the enzyme’s catalytic pocket.

Within laboratory studies, PDE5 inhibitors are commonly used to explore intracellular signaling pathways involving cyclic nucleotides. These compounds may interact with the catalytic region of PDE5 enzymes, preventing the hydrolysis of cGMP and thereby modifying downstream signaling cascades in biochemical assays.

Because amino-modified derivatives introduce small structural changes, researchers may analyze them to determine:

• enzyme binding affinity
• molecular conformation and catalytic inhibition
• structure-activity relationships among PDE inhibitors
• comparative selectivity against other phosphodiesterase families

Mechanism of Action in Experimental Systems

PDE5 Enzyme Inhibition

PDE5 is an enzyme responsible for breaking down cyclic guanosine monophosphate (cGMP), a signaling molecule involved in nitric-oxide-dependent biochemical pathways. Inhibition of PDE5 reduces the rate at which cGMP is hydrolyzed into inactive forms.

Experimental PDE5 inhibitors interact with the enzyme’s catalytic region through specific hydrogen-bond and hydrophobic interactions, stabilizing the inhibitor within the active site and preventing enzymatic activity.

Modulation of cGMP Signaling

In biochemical assays, reduced PDE5 activity increases cGMP signaling levels in cellular systems. This modulation allows researchers to study:

• cyclic nucleotide signaling pathways
• nitric-oxide-dependent signaling cascades
• enzyme kinetics and regulatory feedback mechanisms

Molecular Structure-Activity Studies

Derivatives such as amino-substituted analogs are also investigated in structure-activity relationship (SAR) research. Structural modifications may alter how the compound interacts with enzyme binding pockets, potentially affecting selectivity, affinity, or metabolic stability.

Research Applications

In controlled laboratory environments, Amino Tadalafil may be used in studies examining:

• phosphodiesterase enzyme inhibition
• cyclic nucleotide metabolism and signaling pathways
• molecular docking and receptor-binding analysis
• structure-activity relationship investigations among PDE inhibitors
• comparative biochemical assays involving cyclic nucleotide signaling

These investigations are conducted strictly within in vitro or preclinical experimental frameworks.

Research Applications

In controlled laboratory environments, Amino Tadalafil may be utilized for investigations involving:

• phosphodiesterase enzyme inhibition assays
• cyclic nucleotide signaling pathway analysis
• molecular docking and receptor-binding studies
• structure-activity relationship investigations among PDE inhibitor analogs
• biochemical modeling of enzyme-ligand interactions

These investigations are performed exclusively within experimental and analytical research settings.

Why Choose Purerawz?

Buy Amino Tadalafil for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each compound is supplied with an independent third-party Certificate of Analysis verifying identity, purity, and concentration.

Note: Amino Tadalafil is an investigational compound currently undergoing scientific evaluation and has not been established as safe or effective for any therapeutic application.

Disclaimer

This information is for educational purposes only and does not constitute medical advice.

THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the Institutional Animal Care and Use Committee (IACUC) in accordance with the guidelines of the Animal Welfare Act (AWA).

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Reference Links

Discovery of tadalafil as a highly selective phosphodiesterase-5 inhibitor – Journal of Medicinal Chemistry
https://pubmed.ncbi.nlm.nih.gov/14521415/

Tadalafil mechanism of action and PDE5 inhibition – StatPearls (NCBI)
https://www.ncbi.nlm.nih.gov/books/NBK603743/

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