Fladrafinil

Overview of Fladrafinil (CRL-40,941)

Fladrafinil (CRL-40,941) is a synthetic compound structurally related to Adrafinil, belonging to a group of molecules sometimes described as eugeroics.

Chemically, Fladrafinil contains fluorinated phenyl groups that differentiate it from its structural predecessor, Adrafinil.

These modifications were explored in early research to evaluate how changes in molecular structure might influence CNS signaling and behavioral responses in experimental preclinical models.

Property	Description
Compound Name	Fladrafinil
PubChem CID	13316557
Alternative Name	CRL-40,941
Chemical Structure
Chemical Class	Eugeroic / Adrafinil derivative
CAS Number	90212-80-9
Molecular Formula	C15H13F2NO3S
Molecular Weight	325.3 g/mol
IUPAC Name	2-[bis(4-fluorophenyl)methylsulfinyl]-N-hydroxyacetamide

Working Mechanism of Fladrafinil

The exact pharmacological mechanism of Fladrafinil has not been fully characterized. However, due to its structural relationship with Adrafinil and Modafinil, researchers have proposed that it may interact with central nervous system neurotransmitter pathways.

Studies involving related compounds suggest possible interactions with:

• dopaminergic signaling systems
• serotonergic neurotransmission
• histamine and orexin pathways associated with wakefulness
• GABA-related neural signaling

Why Buy Fladrafinil from Purerawz?

Purerawz supplies laboratory-grade research compounds verified through third-party testing. Each batch includes an independent Certificate of Analysis (COA) confirming identity and purity.

Disclaimer

The information provided is intended for educational and research reference purposes only.

All products sold by PureRawz are intended strictly for laboratory and scientific research use and are not approved for human or veterinary consumption.

Research must be conducted by qualified professionals and should follow appropriate oversight procedures, including IRB or IACUC guidelines where applicable.

Reference Links

Minzenberg, M. J., & Carter, C. S. (2008). Modafinil: A review of neurochemical actions and effects on cognition. Neuropsychopharmacology, 33(7), 1477 1502. https://doi.org/10.1038/sj.npp.1301534

“GSRS.” Nih.gov, 2026, gsrs.ncats.nih.gov/ginas/app/ui/substances/5RT6X0M01F.

“NCATS Inxight Drugs — FLADRAFINIL.” Ncats.io, 2025, drugs.ncats.io/substance/5RT6X0M01F.Accessed 11 Mar. 2026.

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