Stenabolic (SR-9009)

What Is Stenabolic (SR9009)?

SR9009 has been examined within controlled laboratory environments for investigational purposes. 

In preclinical experimental systems, the compound has been studied to evaluate its potential influence on energy-related biochemical pathways. It may also be studied for its possible influence on gene expression patterns. Researchers have observed in preclinical models that SR9009 may use stored lipid substrate for energy generation.It is important to note that SR9009 is primarily characterized as a research compound intended for investigational use in scientific studies.

Chemical Information

Property	Details
Product Name	Stenabolic (SR9009)
Synonyms	SR-9009, Synthetic Rev-Erb Agonist
Chemical Formula	C20H24ClN3O4S
Molecular Weight	437.94 g/mol

How Does Stenabolic Work?

SR9009 is commonly studied as a synthetic ligand/agonist of the REV-ERB nuclear receptors (REV-ERBα and REV-ERBβ). These receptors function as transcriptional regulators. That means they may influence the expression of specific genes, including those linked to circadian clock pathways and biochemical processes.

Research Applications of Stenabolic (SR 9009)

Stenabolic (SR 900) is under investigation. So far, researchers have found the following about the product. 

Though more research is required for long-term research purposes:

• Used as a reference agonist in receptor binding and signaling assays to investigate REV–ERBα/β nuclear receptor activation mechanisms.
• Applied in reporter gene assays and molecular pathway models to analyze the regulation of circadian-related transcription networks
• Used in structure–activity relationship (SAR) studies and molecular docking simulations to design and compare new REV-ERB modulators.

Note: Such observations are limited to experimental models and are intended solely for mechanistic and analytical research purposes.

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Disclaimer

This information is for educational and research purposes only. It should not be used to diagnose, treat, or prevent any disease. Do not use SR9009 in humans. Only trained labs should handle it under approved IRB / IACUC protocols. Always verify scientific findings through trusted journals before use in research.

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Reference Links

Li, H., Song, S., Tien, C., Qi, L., Graves, A., Nasiotis, E., Burris, T. P., Zhao, Y., Sun, Z., & Zhang, L. (2022). SR9009 improves heart function after pressure overload independent of cardiac REV-ERB. Frontiers in Cardiovascular Medicine, 9. https://doi.org/10.3389/fcvm.2022.952114

Saiz, N., Herrera-Castillo, L., Isorna, E., Delgado, M. J., Conde-Sieira, M., Soengas, J. L., & de Pedro, N. (2022). REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish. International Journal of Molecular Sciences, 23(6), 2921. https://doi.org/10.3390/ijms23062921

Dierickx, P., Emmett, M. J., Jiang, C., Uehara, K., Liu, M., Adlanmerini, M., & Lazar, M. A. (2019). SR9009 has REV-ERB–independent effects on cell proliferation and metabolism. Proceedings of the National Academy of Sciences, 116(25), 12147–12152. https://doi.org/10.1073/pnas.1904226116

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