PT-141

Overview of Alpha-Melanocyte-Stimulating Hormone (α-MSH)

Alpha-Melanocyte-Stimulating Hormone (α-MSH) is a naturally occurring peptide derived from the precursor protein proopiomelanocortin (POMC). 

α-MSH has been investigated in research literature for potential roles in signaling pathways. In research studies, these pathways are believed to be associated with pigmentation, endocrine signaling, and immunomodulatory mechanisms. 

As an investigational peptide, α-MSH may be of interest to researchers exploring receptor-mediated signaling networks and downstream molecular responses. 

Current research studies continue to examine how α-MSH might influence intracellular signaling cascades under controlled laboratory conditions. 

Proposed Mechanism of Action of α-MSH

α-MSH is an endogenous agonist of multiple melanocortin receptors (primarily MC1R, MC3R, MC4R, and MC5R), with MC1R being the most extensively studied in pigmentation research. 

Upon receptor activation, adenylyl cyclase is stimulated, resulting in increased intracellular cAMP production. Research studies suggest that α-MSH may modulate cellular signaling through pathways associated with:

• Receptor-mediated second messenger signaling
• Regulation of gene expression
• Cellular communication related to pigment biosynthesis
• It has been examined for effects on signaling molecules involved in cellular communication. 

In preclinical research, α-MSH has been examined as a tool for studying melanocortin receptor activity and receptor selectivity. 

Researchers continue to investigate how receptor subtype interactions might affect signaling intensity and duration in various investigational models.

Chemical Properties of α-MSH

PubChem CID	16133793
Molecular Formula	C77H109N21O19S
Molecular Weight	1664.9 g/mol
2D Structure depiction
CAS	581-05-5
Synonyms	581-05-5 Alpha msh alpha Intermedin Intermedin, alpha MSH, alpha

Possible Research Applications of α-MSH

1. Receptor Signaling Research

α-MSH may be used in preclinical research to examine melanocortin receptor activation, ligand binding affinity, and downstream signaling dynamics.

2. Pigmentation Pathway Analysis

Research studies may utilize α-MSH to explore pathways associated with melanin synthesis and transcriptional regulation of pigment-related proteins.

3. Melanocortin Receptor Signaling Studies

Investigational models may use α-MSH to study peptide-mediated intercellular signaling and receptor cross-talk.

FAQs

What is α-MSH?

α-MSH is a naturally occurring peptide hormone derived from POMC and studied for its interaction with melanocortin receptors.

How does α-MSH work in research settings?

It may interact with melanocortin receptors and influence signaling pathways such as cAMP-dependent cascades, depending on experimental conditions.

Why is α-MSH studied in preclinical research?

Researchers may use α-MSH to investigate receptor signaling, peptide-receptor interactions, and downstream molecular responses.

Can α-MSH be used for human consumption?

No. This material is intended strictly for laboratory and research applications and is not intended for human use.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.

Reference Links

• Millington, G. W. M. (2010). Alpha-melanocyte-stimulating hormone: Production and degradation. Journal of Endocrinology, 206(3), 271–281. https://doi.org/10.1677/JOE-10-0191
  PubMed: PMID 20617297
• Catania, A., Airaghi, L., Colombo, G., & Lipton, J. M. (2000). Alpha-melanocyte-stimulating hormone in normal human physiology and disease states. Trends in Endocrinology & Metabolism, 11(8), 304–308. https://doi.org/10.1016/S1043-2760(00)00296-4
  PubMed: PMID 10996524Thody, A. J. (1999). Alpha-MSH and the regulation of melanocyte function. Annals of the New York Academy of Sciences, 885, 217–229. https://doi.org/10.1111/j.1749-6632.1999.tb08679.x
  PubMed: PMID 10816655

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All products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.